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Drug Discovery Today Disease Mechanisms
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Drug Discovery Today Disease Mechanisms
Article . 2006 . Peer-reviewed
License: Elsevier TDM
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Drug Discovery Today Disease Mechanisms
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https://dx.doi.org/10.1016/j.d...
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Mechanisms and inhibition of HIV integration

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2006 English Publisher:Elsevier BVJournal:Drug Discovery Today: Disease Mechanisms, volume 3, pages 253-260 (issn: 1740-6765, Copyright policy )
Authors: Christophe, Marchand; Allison A, Johnson; Elena, Semenova; Yves, Pommier;

doi: 10.1016/j.ddmec.2006.05.004

pmid: 20431697

pmc: PMC2860614

Mechanisms and inhibition of HIV integration

Abstract

HIV integrase is required for viral replication and a rationale target for antiretroviral therapies. Integrase inhibitors are potentially complementary to current treatments. This review focuses on the mechanisms of HIV integration. The roles of viral and cellular co-factors during pre-integration complex (PIC) formation and integration are reviewed. The biochemical mechanisms of integration, integrase structures and approaches to inhibit integration are described.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
21
Top 10%
Top 10%
Top 10%
bronze