
pmid: 15062641
Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor and a receptor accessory protein. These two molecules are members of a wider family of proteins that have in common the presence of immunoglobulin domains in the extracellular region of the protein and a TIR domain in the cytoplasmic region. The nature of this family of proteins and their signal transduction pathway is discussed in this review.
Receptors, Interleukin-18, Membrane Glycoproteins, Sequence Homology, Amino Acid, Molecular Sequence Data, Models, Immunological, Membrane Proteins, Proteins, Receptors, Interleukin-1, Receptors, Cell Surface, Receptors, Interleukin, Interleukin-1 Receptor-Like 1 Protein, Evolution, Molecular, Multigene Family, Animals, Humans, Amino Acid Sequence, Interleukin-1 Receptor Accessory Protein, Interleukin-18 Receptor alpha Subunit, Phylogeny, Signal Transduction
Receptors, Interleukin-18, Membrane Glycoproteins, Sequence Homology, Amino Acid, Molecular Sequence Data, Models, Immunological, Membrane Proteins, Proteins, Receptors, Interleukin-1, Receptors, Cell Surface, Receptors, Interleukin, Interleukin-1 Receptor-Like 1 Protein, Evolution, Molecular, Multigene Family, Animals, Humans, Amino Acid Sequence, Interleukin-1 Receptor Accessory Protein, Interleukin-18 Receptor alpha Subunit, Phylogeny, Signal Transduction
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