Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
Copyright policy )Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form high, intermediate, and low-affinity receptors. IL-2Ralpha and IL-2Rbeta, respectively, are markers for double-negative thymocytes and regulatory T-cells versus memory cells. gamma(c), which is shared by six cytokines, is mutated in patients with X-linked severe-combined immunodeficiency. We now cover an under-reviewed area-the regulation of genes encoding IL-2 and IL-2R components, with an effort to integrate/explain this knowledge.
- National Institute of Health Pakistan
- Centre de Recherche en Cancérologie de Marseille France
- Yonsei University Health System Korea (Republic of)
- French Institute of Health and Medical Research France
- National Institutes of Health United States
RNA Processing, 570, NF-kappa B/physiology, 610, Interleukin-2 Receptor beta Subunit/genetics, Cyclic AMP Response Element Modulator, STAT5 Transcription Factor/physiology, Mice, Interleukin-2 Receptor alpha Subunit/genetics, Post-Transcriptional/physiology, Receptors, STAT5 Transcription Factor, Animals, Humans, Interleukin-2/genetics*, RNA Processing, Post-Transcriptional, γc, Cyclic AMP Response Element-Binding Protein, NFATC Transcription Factors, Cyclic AMP Response Element-Binding Protein/physiology, IL-2, Transcription Factor AP-1/physiology, Interleukin-2 Receptor alpha Subunit, NF-kappa B, Cyclic AMP Response Element Modulator/physiology, Receptors, Interleukin-2, IL-2 receptor, Interleukin-2 Receptor beta Subunit, Transcription Factor AP-1, Phenotype, NFATC Transcription Factors/physiology, Gene Expression Regulation, XSCID, Interleukin-2, Transcription
RNA Processing, 570, NF-kappa B/physiology, 610, Interleukin-2 Receptor beta Subunit/genetics, Cyclic AMP Response Element Modulator, STAT5 Transcription Factor/physiology, Mice, Interleukin-2 Receptor alpha Subunit/genetics, Post-Transcriptional/physiology, Receptors, STAT5 Transcription Factor, Animals, Humans, Interleukin-2/genetics*, RNA Processing, Post-Transcriptional, γc, Cyclic AMP Response Element-Binding Protein, NFATC Transcription Factors, Cyclic AMP Response Element-Binding Protein/physiology, IL-2, Transcription Factor AP-1/physiology, Interleukin-2 Receptor alpha Subunit, NF-kappa B, Cyclic AMP Response Element Modulator/physiology, Receptors, Interleukin-2, IL-2 receptor, Interleukin-2 Receptor beta Subunit, Transcription Factor AP-1, Phenotype, NFATC Transcription Factors/physiology, Gene Expression Regulation, XSCID, Interleukin-2, Transcription
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