LPS/TLR4 signal transduction pathway

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2008 English Publisher:Elsevier BVJournal:Cytokine, volume 42, pages 145-151 (issn: 1043-4666,

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Authors: Yong-Chen, Lu; Wen-Chen, Yeh; Pamela S, Ohashi;

doi: 10.1016/j.cyto.2008.01.006

pmid: 18304834

LPS/TLR4 signal transduction pathway

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Abstract

The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway.

Related Organizations

University of Toronto
Canada
Ontario Institute for Cancer Research
Canada

Keywords

Lipopolysaccharides, Toll-Like Receptor 4, Animals, Humans, Signal Transduction

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