Transmissible spongiform encephalopathies in ruminants

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2004 English Publisher:Elsevier BVJournal:Veterinary Clinics of North America: Food Animal Practice, volume 20, pages 303-326 (issn: 0749-0720,

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Authors: Jeff W, Tyler; John R, Middleton;

doi: 10.1016/j.cvfa.2004.02.002

pmid: 15203228

Transmissible spongiform encephalopathies in ruminants

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Abstract

Transmissible spongiform encephalopathies (TSEs) have been observed in North American sheep, cervidae, and cattle. The causative agent of TSEs seems to be proteins that induce a conformational change in normal host proteins. Common clinical signs ofTSEs include chronic weight loss and deteriorating neurologic function. Mechanisms of TSE transmission vary among host species. The diagnostic approach for TSEs of ruminants is presented,and the history and justification of regulatory programs to control and eradicate TSEs are outlined.

Related Organizations

University of Missouri
United States

Keywords

Encephalopathy, Bovine Spongiform, Sheep, Animals, Wasting Disease, Chronic, Cattle, Ruminants, Prion Diseases, Scrapie

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