The majority of rabbit skin disease presentations can be divided into pruritus, alopecia, scaling, and nodules. Some disease will have more than one of these clinical signs. Ectoparasites, bacterial and fungal infections, and neoplasia account for most of the causes seen. Diagnostic tests include skin scraping and cytology, microbial culture, and biopsy. Therapy is dependent on cause. In addition to discussing the various causes and their treatments, important clinical care points are noted.