Name: Mitotic Kinesins: A Reason to Delve into Kinesin-12
Creator: William O. Hancock
Keywords: 0301 basic medicine, 03 medical and health sciences, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Cell Cycle, Humans, Kinesins, Spindle Apparatus, Kinetochores, Microtubules

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2014 English Publisher:Elsevier BVJournal:Current Biology, volume 24, pages R968-R970 (issn: 0960-9822,

Authors: William O. Hancock;

doi: 10.1016/j.cub.2014.09.011

pmid: 25291641

Mitotic Kinesins: A Reason to Delve into Kinesin-12

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Abstract

The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.

Related Organizations

Pennsylvania State University
United States

Keywords

Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Cell Cycle, Humans, Kinesins, Spindle Apparatus, Kinetochores, Microtubules

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