Mitosis: Short-Circuiting Spindle Checkpoint Signaling
Copyright policy )Mitosis: Short-Circuiting Spindle Checkpoint Signaling
The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.
- Howard Hughes Medical Institute United States
- The University of Texas Southwestern Medical Center United States
Saccharomyces cerevisiae Proteins, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), M Phase Cell Cycle Checkpoints, Mitosis, Nuclear Proteins, Cell Cycle Proteins, Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), M Phase Cell Cycle Checkpoints, Mitosis, Nuclear Proteins, Cell Cycle Proteins, Saccharomyces cerevisiae
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