Cancer stem cells hypothesis and stem cells in head and neck cancers
Copyright policy )Cancer stem cells hypothesis and stem cells in head and neck cancers
There is increasing evidence that the growth and spread of cancer is driven by a small subpopulation of cancer cells, defined as cancer stem cells (CSCs). Recent data indicate that the initiation, growth, recurrence and metastasis of cancers are related to the behavior of a small population of malignant cells with properties of stem cells, and information about them are potentially helpful in identifying the target for the tumor's therapeutic elimination. The presence of subpopulation cells with phenotypic and behavioral characteristics corresponding to both normal epithelial stem cells and to cells capable of initiating tumors has been also reported in head and neck squamous cell carcinomas (HNSCCs).
- University of Florence Italy
Squamous Cell Carcinoma of Head and Neck, Stem Cells, Retinal Dehydrogenase, Animals, Antigens; CD; metabolism, Antigens; CD44; metabolism, Biological Markers, Carcinoma; Squamous Cell; pathology, Cell Transformation; Neoplastic; pathology, Drug Resistance; Neoplasm, Glycoproteins; metabolism, Head and Neck Neoplasms; drug therapy/pathology/radiotherapy, Humans, Isoenzymes; analysis, Neoplasm Metastasis; immunology/pathology, Neoplastic Stem Cells; metabolism/pathology, Peptides; metabolism, Retinal Dehydrogenase; analysis, Stem Cells; pathology, Treatment Outcome, Tumor Markers; Biological; metabolism, Aldehyde Dehydrogenase 1 Family, Isoenzymes, Cell Transformation, Neoplastic, Hyaluronan Receptors, Antigens, CD, Drug Resistance, Neoplasm, Head and Neck Neoplasms, Biomarkers, Tumor, Carcinoma, Squamous Cell, Neoplastic Stem Cells, Animals, Humans, AC133 Antigen, Neoplasm Metastasis, Peptides, Biomarkers, Glycoproteins
Squamous Cell Carcinoma of Head and Neck, Stem Cells, Retinal Dehydrogenase, Animals, Antigens; CD; metabolism, Antigens; CD44; metabolism, Biological Markers, Carcinoma; Squamous Cell; pathology, Cell Transformation; Neoplastic; pathology, Drug Resistance; Neoplasm, Glycoproteins; metabolism, Head and Neck Neoplasms; drug therapy/pathology/radiotherapy, Humans, Isoenzymes; analysis, Neoplasm Metastasis; immunology/pathology, Neoplastic Stem Cells; metabolism/pathology, Peptides; metabolism, Retinal Dehydrogenase; analysis, Stem Cells; pathology, Treatment Outcome, Tumor Markers; Biological; metabolism, Aldehyde Dehydrogenase 1 Family, Isoenzymes, Cell Transformation, Neoplastic, Hyaluronan Receptors, Antigens, CD, Drug Resistance, Neoplasm, Head and Neck Neoplasms, Biomarkers, Tumor, Carcinoma, Squamous Cell, Neoplastic Stem Cells, Animals, Humans, AC133 Antigen, Neoplasm Metastasis, Peptides, Biomarkers, Glycoproteins
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