Statistics is a set of tools used in medical decision-making no different than how a scalpel or a sagittal saw is used in the operating room. No foot and ankle surgeon is born with the inherent ability to perform, understand, and critically interpret them. Instead, it requires training and practice throughout the course of a career in medicine to develop a working proficiency. This article reviews the basic indications and interpretation of common descriptive and comparative statistical tests in the podiatric literature. Additionally, the concept of which tests are most appropriate for which investigational methodologies is introduced.