Humans are prone to mentally organise the ascending series of integers according to reading habits so that in western cultures small numbers are positioned to the left of larger ones on a mental number line. Despite 140 years since seminal observations by Sir Francis Galton (Galton, 1880a, b), the functional mechanisms that give rise to directional Space-Number Associations (SNAs) remain elusive. Here, we contrasted three different experimental conditions, each including a different version of a Go/No-Go task with intermixed numerical and arrow-targets (Shaki and Fischer, 2018; Pinto et al., 2019a). We show that directional SNAs are not "all or none" phenomena. We demonstrate that SNAs get progressively less noisy and more stable the more contrasting small/large magnitude-codes and contrasting left/right spatial-codes are explicitly and fully combined in the task set. The analyses of the time-course of space-number congruency effects showed that both the absence and presence of the SNA were independent of the speed of reaction times. In agreement with our original proposal (Aiello et al., 2012), these findings show that conceptualising the ascending series of integers in spatial terms depends on the use of spatial codes in the numerical task at hand rather than on the presence of an inherent spatial dimension in the semantic representation of numbers. This evidence suggests that directional SNAs, like the SNARC effect, are secondary to the primary transfer of spatial response codes to number stimuli, rather than deriving from a primary congruency or incongruence between independent spatial-response and spatial-number codes.