The incidence of skin cancer has been increasing throughout the United States and much of the world. Although the mortality rate of nonmelanoma skin cancer is low, that type of skin cancer accounts for considerable morbidity, including cosmetic and functional impairment. Melanoma, although less common, is a life-threatening malignancy if not detected and treated early. Skin cancer also significantly contributes to the rising costs of health care in the United States. Prevention, early diagnosis, and treatment are critical in helping to reduce the incidence, morbidity, and mortality associated with skin cancer. This article provides an introduction to skin cancer, including the changing incidence, clinical presentation, and summary of treatment and prognosis.