Covalent bonds form the skeleton of molecules while non-covalent interactions allow them to modulate their shape and some of their characteristics. The lability of the non-covalent interactions due to subtle changes in the environment is of primary importance in biochemical processes. Thus, for instance, the interaction of a hormone with a receptor can produce a cascade of processes many of them closely related to the formation or rupture of non-covalent interactions. At the computational level, reproducing covalent bonds or strong interactions can currently be carried out relatively easily. In contrast, as the interactions become weaker they are more difficult to describe properly. Thanks to recent advances in computational resources and methodology, it has become possible during the last few years to study with great detail non-covalent interactions and, in many cases, to describe for the first time an increasing number of them. In this issue, some of the leading groups involved in the study of weak interactions show the state of the art in the computational study of non-covalent interactions

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