The human brain presents ongoing temporal fluctuations whose dynamic range indicates the capacity of information processing and can be approximately quantified with entropy. Using functional magnetic resonance imaging (fMRI), recent studies have shown a stable distribution pattern of temporal brain entropy (tBEN) in healthy subjects, which may be affected by neuropsychiatric diseases such as schizophrenia. Assessing tBEN may reciprocally provide a new tool to characterize those disorders.The current study aimed to identify tBEN changes in schizophrenia patients using publicly available data from the Centers of Biomedical Research Excellence (COBRE) project. Forty-three schizophrenia patients and 59 sex- and age-matched healthy control subjects were included, and tBEN was calculated from their resting-state fMRI scans.Compared with healthy controls, patients showed decreased tBEN in the right middle prefrontal cortex, bilateral thalamus, right hippocampus and bilateral caudate and increased tBEN in the left lingual gyrus, left precuneus, right fusiform face area and right superior occipital gyrus. In schizophrenia patients, tBEN in the left cuneus and middle occipital gyrus was negatively correlated with the positive and negative syndrome scores (PANSS). Age of onset was inversely correlated with tBEN in the right fusiform gyrus and left insula.Our findings demonstrate a detrimental tBEN reduction in schizophrenia that is related to clinical characteristics. The tBEN increase in a few regions might be a result of tBEN redistribution across the whole brain in schizophrenia.