Abstract The mechanical properties of polymer core materials in sandwich structures are often degraded by moisture that is absorbed during storage. To date, there is no reliable model to predict the amount of moisture that is present in these sandwich core materials. A multi-layer diffusion model applicable to these sandwich structures is described in this report. Inputs to this model are: (1) diffusivities of core and face sheet materials as functions of temperature, (2) moisture saturation data as a function of relative humidity, and (3) sandwich structure exposure history. The output is a prediction of the amounts of moisture in the core material and face sheets as a function of time. In order to validate this model, moisture diffusion experiments were performed on a sandwich material consisting of graphite–epoxy face sheets and a core of Rohacell ® polymethacrylimide 200WF foam. Samples of this material were dried, and then hydrated at either 32 °C or 65 °C at either 83% or 100% relative humidity. The face sheets were separated from the core and each component was weighed, dried, and weighed again in order to determine the moisture distribution in the sandwich structure. The results were then compared with the model predictions.