miRNA and tropism of human parvovirus B19

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2012 English Publisher:Elsevier BVJournal:Computational Biology and Chemistry, volume 40, pages 1-6 (issn: 1476-9271,

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Authors: Olga Berillo; Vladimir Khailenko; Anatoly Ivashchenko; Lior Perlmuter-Shoshany; Alexander Bolshoy;

doi: 10.1016/j.compbiolchem.2012.06.002

pmid: 22902951

handle: 11858/00-001M-0000-000E-E888-F , 11858/00-001M-0000-000E-EBFA-8

miRNA and tropism of human parvovirus B19

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Abstract

Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it.

Related Organizations

Al-Farabi Kazakh National University
Kazakhstan
University of Haifa
Israel

Keywords

MicroRNAs, Molecular Sequence Data, Parvovirus B19, Human, Computational Biology, Humans, Amino Acid Sequence, RNA, Messenger, Host Specificity, Introns

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