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Plasticity of CD4+ FoxP3+ T cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2009 Switzerland English Publisher:Elsevier BVJournal:Current Opinion in Immunology, volume 21, pages 281-285 (issn: 0952-7915,

Authors: Zhou, Xuyu; Bailey-Bucktrout, Samantha; Jeker, Lukas T.; Bluestone, Jeffrey A.;

doi: 10.1016/j.coi.2009.05.007

pmid: 19500966

pmc: PMC2733784

Plasticity of CD4+ FoxP3+ T cells

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Abstract

Regulatory T (Treg) cells play an essential role in maintaining immunological tolerance. The discovery of FoxP3 as a key Treg transcription factor combined with recent advances in the development of functional reporter mice has enabled new insights into Treg biology and revealed unexpected features of this lineage. In this review, we address the stability of this population, focusing on studies that suggest that Tregs can downregulate FoxP3, lose regulatory activity and, under some conditions, become memory T cells capable of recognizing self-antigens and expressing effector cell activities including the production of IL-17 and IFNgamma. The presence of these 'exTregs' in multiple inflammatory settings suggests a potential role for these cells in a variety of disease settings ranging from autoimmunity to cancer and infectious disease.

Country

Switzerland

Related Organizations

University of Basel
Switzerland
University of California System
United States
University of California, San Francisco
United States

Keywords

CD4-Positive T-Lymphocytes, Interferon-gamma, Interleukin-17, Animals, Gene Expression, Humans, Cell Lineage, Forkhead Transcription Factors, Immunologic Memory

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
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