New insights into pathways for CD1-mediated antigen presentation
Copyright policy )New insights into pathways for CD1-mediated antigen presentation
Recent studies of CD1 structure and intracellular trafficking have demonstrated significant differences among the CD1 isoforms (CD1a, CD1b, CD1c and CD1d). The molecular and structural basis for the differential trafficking of CD1 molecules has also been delineated. These observations broaden our understanding of why the immune system has evolved multiple CD1 isoforms to survey different cellular compartments for lipid antigen presentation, to provide host defense against the microbial world and to offer immunoregulation with relevance to tumor immunity and autoimmunity.
- Nippon Medical School Japan
- Brigham and Women's Faulkner Hospital United States
- Harvard University United States
Models, Molecular, Antigen Presentation, Histocompatibility Antigens Class II, Endocytosis, Antigens, CD1, Mice, Protein Transport, Endopeptidases, Animals, Humans
Models, Molecular, Antigen Presentation, Histocompatibility Antigens Class II, Endocytosis, Antigens, CD1, Mice, Protein Transport, Endopeptidases, Animals, Humans
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).56 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!