Perioperative care is comprised of preoperative, intraoperative, and postoperative care. Given the vulnerable status of the perioperative patient, coupled with the complex nature of these areas, evidence-based practice and clinical decision-making must be rooted in high-quality evidence for safe and effective patient and family care. Evidence-based practice is comprised of patient and family preferences, clinical expertise, and best available evidence. This article showcases systematic reviews that have focused on clinical issues within the preoperative, intraoperative, and postoperative care areas. A case study presents the importance of applying best available evidence to solve a thorny clinical problem and improve patient outcomes.