Entropy is the amount of energy which is lost during any irreversible process. Here our main focus is that how can we reduce this energy loss to enhance the capability of our system. Blood is an example of Eyring-Powell fluid. Many strategies are used to rise the capacity of heat transport. Heat transport can be enhanced by intensifying the materials thermal conductivity through nanoparticles. Thermal conductivity of the material can be enhanced by adding nanoparticles in base fluid. The objective of this work is to discuss entropy generation in MHD Eyring-Powell nanofluid flow. The flow is generated by a linear stretchable surface. Current analysis includes the effects of viscous dissipation, nonlinear mixed convection and Joule heating. Nanoparticles analyzed the consequences of Brownian motion and thermophoresis effects.The boundary layer flow equations are solved for series solutions by applying homotopic technique.Graphical results of involved quantities like entropy generation, velocity, concentration and thermal fields are presented. Skin friction, Sherwood and Nusselt number are numerically scrutinized.