AMPK Promotes Autophagy by Facilitating Mitochondrial Fission

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2016 English Publisher:Elsevier BVJournal:Cell Metabolism, volume 23, pages 399-401 (issn: 1550-4131,

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Authors: Zhang, Chen-Song; Lin, Sheng-Cai;

doi: 10.1016/j.cmet.2016.02.017

pmid: 26959181

AMPK Promotes Autophagy by Facilitating Mitochondrial Fission

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Abstract

AMPK senses decreased cellular energy levels, triggering mitochondrial autophagy or mitophagy through activating ULK1 and inhibiting mTORC1. In a recent report, Toyama et al. (2016) show that activated AMPK phosphorylation of MFF is critical for mitochondrial fission. Unphosphorylatable MFF mutants block mitophagy, connecting AMPK to mitochondrial fission and to mitophagy.

Related Organizations

Xiamen University
China (People's Republic of)
State Key Laboratory of Cell Stress Biology
China (People's Republic of)

Keywords

Physiology, Stress, Physiological, Humans, Cell Biology, AMP-Activated Protein Kinases, Energy Metabolism, Molecular Biology, Mitochondrial Dynamics, Mitochondria

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