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Cardiolipin and the Nlrp3 Inflammasome

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2013 English Publisher:Elsevier BVJournal:Cell Metabolism, volume 18, pages 610-612 (issn: 1550-4131, Copyright policy )Publicly fundedFunded by:EC | MICROINNATE
Authors: O'NEILL, LUKE;

doi: 10.1016/j.cmet.2013.10.013

pmid: 24206659

handle: 2262/72207

Cardiolipin and the Nlrp3 Inflammasome

Abstract

The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting inflammation.

Related Organizations
Keywords

570, Physiology, Cardiolipins, Inflammasomes, 610, Cell Biology, Biochemistry, Mitochondria, Animals, Humans, Carrier Proteins, Molecular Biology

  • BIP!
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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 30
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
30
Top 10%
Average
Average
Green
hybrid
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