BDNF (I)rising from Exercise
Copyright policy )BDNF (I)rising from Exercise
Exercise produces many beneficial effects on brain health, in part by increasing hippocampal BDNF levels; however, the mechanism underlying BDNF gene regulation remains unknown. In this issue of Cell Metabolism, Wrann et al. (2013) show that exercise induces hippocampal Bdnf expression by stimulating expression of FNDC5, the precursor of irisin, via the transcriptional complex PGC-1α/Errα.
- Department of Medicine Italy
- Scripps Research Institute United States
Male, Physiology, Brain-Derived Neurotrophic Factor, Physical Conditioning, Animal, Animals, Humans, Cell Biology, Molecular Biology, Hippocampus, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Fibronectins, Signal Transduction, Transcription Factors
Male, Physiology, Brain-Derived Neurotrophic Factor, Physical Conditioning, Animal, Animals, Humans, Cell Biology, Molecular Biology, Hippocampus, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Fibronectins, Signal Transduction, Transcription Factors
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