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Hyperinsulinism in the Neonate

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2018Publisher:Elsevier BVJournal:Clinics in Perinatology, volume 45, pages 61-74 (issn: 0095-5108,

Authors: Katherine Lord; Diva D. De León; Diva D. De León;

doi: 10.1016/j.clp.2017.10.007

pmid: 29406007

Hyperinsulinism in the Neonate

- Summary
- Subjects
- Metrics

Abstract

Hyperinsulinism (HI) is the leading cause of persistent hypoglycemia in infants. Prompt recognition and treatment, independent of whether infants have transient or permanent HI, are essential to decrease risk of neurologic damage. The most common form of congenital HI is due to inactivating mutations of the β-cell ATP-sensitive potassium (KATP) channel (KATP-HI) and is typically diazoxide unresponsive. KATP-HI occurs in diffuse and focal forms. Distinguishing between the 2 forms is crucial, because pancreatectomy is curative in the focal form but palliative in the diffuse form. The 18-fluoro-L-3,4-dihydroxyphenylalanine PET scan has revolutionized HI management by allowing accurate localization of focal lesions prior to surgery.

Related Organizations

University of Pennsylvania
United States
Children's Hospital of Philadelphia
United States

Keywords

Beckwith-Wiedemann Syndrome, Sotos Syndrome, Diazoxide, Infant, Newborn, Turner Syndrome, Hematologic Diseases, Vestibular Diseases, Stress, Physiological, Face, Hyperinsulinism, Humans, Abnormalities, Multiple, Congenital Hyperinsulinism, Genetic Testing, Antihypertensive Agents

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	40
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%