Recent classification systems of cerebral palsy call for an assessment of the timing and etiology of brain injury. The placenta is an underused resource for addressing these important questions. An expert assessment of the placental pathology can provide temporally and mechanistically specific data not available from any other source. Key concepts for an understanding of the role of placental pathology are the "sentinel lesion," the high prevalence of thromboinflammatory lesions affecting large fetal placental vessels, the significance of underlying placental reserve, and the realization that placental findings can serve as markers for processes occurring in the mother or fetus.