Introduction A 78-year-old man presented to our hospital with an indurated, painful lesion on the abdominal wall at the site of a recent subcutaneous (SC) bortezomib injection. The patient was diagnosed with multiple myeloma (MM) in 2007 after a bone marrow biopsy was done as part of anemia workup. He was started on melphalan and prednisone, which he successfully completed in December of 2007. He experienced a recurrence of MM in March of 2009 and was started on intravenous bortezomib and dexamethasone. In May of 2009, lenalidomide was substituted for bortezomib secondary to bortezomib-induced neuropathy. In January of 2010, his treatment was changed to thalidomide and dexamethasone secondary to lenalidomide-induced skin rash. Due to a favorable response, the treatment was discontinued in January of 2011. Secondary to new onset pancytopenia, a repeated bone marrow biopsy was performed in August of 2011, which confirmed the relapse of the MM. He was started on lenalidomide and dexamethasone orally, as well as bortezomib subcutaneously in August of 2011. After the first SC administration of bortezomib, the patient started to develop a small “boil” at the