HCV NS5A Inhibitors in Development

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2013 English Publisher:Elsevier BVJournal:Clinics in Liver Disease, volume 17, pages 111-121 (issn: 1089-3261,

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Authors: Anna, Suk-Fong Lok;

doi: 10.1016/j.cld.2012.09.006

pmid: 23177287

HCV NS5A Inhibitors in Development

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Abstract

NS5A protein plays a key role in hepatitis C virus (HCV) replication. Daclatasvir (DCV, BMS-790052) is a first-in-class inhibitor of the HCV NS5A replication complex with potent antiviral activity but a low barrier to resistance. DCV as triple therapy in combination with pegylated interferon and ribavirin resulted in a high rate of early virologic response in treatment-naïve patients with genotype 1 infection; as quadruple therapy in combination with asunaprevir (BMS-650032, NS3 protease inhibitor), pegylated interferon, and ribavirin, it resulted in a high rate of sustained virologic response in genotype 1 prior null responders.

Related Organizations

University of Michigan–Flint
United States
University of Michigan–Ann Arbor
United States
Michigan Medicine
United States

Keywords

Sulfonamides, Pyrrolidines, Interleukins, Imidazoles, Interferon-alpha, Valine, Hepacivirus, Interferon alpha-2, Viral Nonstructural Proteins, Isoquinolines, Antiviral Agents, Hepatitis C, Recombinant Proteins, Polyethylene Glycols, Ribavirin, Humans, Drug Therapy, Combination, Protease Inhibitors, Carbamates, Interferons

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