The NS5A Replication Complex Inhibitors: Difference Makers?
Copyright policy )The NS5A Replication Complex Inhibitors: Difference Makers?
The development and approval of direct-acting antiviral agents looks set to transform the treatment of chronic hepatitis C infection. Among the agents in development are novel compounds that inhibit the function of the NS5A protein: a pleiotropic protein with a complex and essential role in viral replication. Preclinical studies have demonstrated the potency of these agents across a broad range of viral genotypes, and in early phase trials, they rapidly suppressed viral replication when administered as monotherapy or in combination with pegylated interferon-α and ribavirin. The discovery and development of NS5A replication complex inhibitors is summarized in this review.
- Bristol-Myers Squibb (Germany) Germany
- University of California, San Diego United States
- University of California, San Diego United States
Clinical Trials as Topic, Pyrrolidines, Imidazoles, Valine, Viral Nonstructural Proteins, Virus Replication, RNA-Dependent RNA Polymerase, Antiviral Agents, Hepatitis C, Drug Discovery, Humans, Carbamates
Clinical Trials as Topic, Pyrrolidines, Imidazoles, Valine, Viral Nonstructural Proteins, Virus Replication, RNA-Dependent RNA Polymerase, Antiviral Agents, Hepatitis C, Drug Discovery, Humans, Carbamates
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