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The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2011Publisher:Elsevier BVJournal:Clinics in Liver Disease, volume 15, pages 611-626 (issn: 1089-3261,

Authors: Eric Lawitz; Fernando E. Membreno;

doi: 10.1016/j.cld.2011.05.003

pmid: 21867940

The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors

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Abstract

This article introduces one of the most diverse classes of direct-acting antivirals for hepatitis C, the nucleoside and non-nucleoside NS5B polymerase inhibitors. Through a systematic review of the published literature, we describe their structure, mechanism of action, issues with resistance, and clinical effectiveness shown in the latest clinical trials. Direct-acting antiviral combination trials that have already shown some early promising results even in the setting of interferon-sparing antiviral regimens are discussed.

Keywords

Clinical Trials as Topic, Guanosine Monophosphate, Humans, Sofosbuvir, Viral Nonstructural Proteins, Uridine Monophosphate, Antiviral Agents, Deoxycytidine, Hepatitis C

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	48
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%