Pathogenesis of hereditary hemochromatosis
Copyright policy )Pathogenesis of hereditary hemochromatosis
Hereditary hemochromatosis comprises several inherited disorders of iron homeostasis characterized by increased gastrointestinal iron absorpstion and resultant tissue iron deposition. The identification of HFE and other genes involved in iron metabolism has greatly expanded our understanding of hereditary hemochromatosis. Two major hypotheses have been proposed to explain the pathogenesis of HFE-related hereditary hemochromatosis: the hepcidin hypothesis and the duodenal crypt cell programming hypothesis.
- Cardinal Glennon Children’s Medical Center United States
- Saint Louis University United States
- University of Mary United States
Duodenum, Iron, Disease Models, Animal, Mice, Hepcidins, Animals, Humans, Genetic Predisposition to Disease, Hemochromatosis, Antimicrobial Cationic Peptides
Duodenum, Iron, Disease Models, Animal, Mice, Hepcidins, Animals, Humans, Genetic Predisposition to Disease, Hemochromatosis, Antimicrobial Cationic Peptides
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