descriptionPublicationkeyboard_double_arrow_right Article 01 May 2015 English Publisher:Elsevier BVJournal:Cell Host & Microbe, volume 17, pages 538-539 (issn: 1931-3128,

Authors: Eckmann, Lars; Stappenbeck, Thaddeus S.;

doi: 10.1016/j.chom.2015.05.001

pmid: 25974292

IgG “Detoxes” the Intestinal Mucosa

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Abstract

Secretory IgA is important in mucosal defense, but other, incompletely understood effectors exist. In this issue of Cell Host & Microbe, Kamada et al. (2015) show that IgG antibodies are produced against surface virulence factors of an intestinal attaching/effacing pathogen, bind to bacteria localized at the epithelium, and direct their destruction by mucosal and translocated neutrophils.

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Keywords

Gastrointestinal Tract, Cancer Research, Virulence Factors, Immunology and Microbiology(all), Animals, Citrobacter rodentium, Molecular Biology, Immunity, Humoral

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