UnZIPping Mechanisms of Effector-Triggered Immunity in Animals

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2012 English Publisher:Elsevier BVJournal:Cell Host & Microbe, volume 11, pages 320-322 (issn: 1931-3128,

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Authors: Kleino, Anni; Silverman, Neal;

doi: 10.1016/j.chom.2012.04.002

pmid: 22520459

pmc: PMC3335200

UnZIPping Mechanisms of Effector-Triggered Immunity in Animals

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Abstract

The mechanisms by which epithelial cells distinguish pathogens from commensal microbes have long puzzled us. Now, McEwan et al. (2012) and Dunbar et al. (2012), in this issue of Cell Host & Microbe, demonstrate that in C. elegans, microbial toxin-induced inhibition of host cellular functions, especially blockade of protein translation, activates the effector-triggered immune response dependent on the transcription factor ZIP-2.

Related Organizations

University of Massachusetts Medical School
United States

Keywords

Cancer Research, Immunology and Microbiology(all), Molecular Biology

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