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HATs On for Drug Resistance

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2011 English Publisher:Elsevier BVJournal:Cell Host & Microbe, volume 9, pages 85-87 (issn: 1931-3128, Copyright policy )
Authors: Jeremy P. Kamil; Donald M. Coen;

doi: 10.1016/j.chom.2011.02.001

pmid: 21320689

pmc: PMC3072411

HATs On for Drug Resistance

Abstract

Mutations in the human cytomegalovirus UL27 gene confer resistance to an inhibitor of the viral protein kinase UL97. Reitsma and colleagues (2011) demonstrate that UL27 destabilizes the Tip60 histone acetyltransferase, setting forth intriguing new mechanisms for antiviral drug resistance and for viral regulation of the cell cycle.

Related Organizations
Keywords

Cancer Research, Immunology and Microbiology(all), Molecular Biology

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 9
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Average
Average
Average
hybrid
Related to Research communities
Knowmad Institut
Cancer Research