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Shedding Light on Metabotropic Glutamate Receptors

Name: Shedding Light on Metabotropic Glutamate Receptors
Creator: NICOLETTI, Ferdinando
Keywords: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Biochemistry; Clinical Biochemistry; Molecular Biology; Molecular Medicine; Drug Discovery3003 Pharmaceutical Science; Pharmacology, Receptors, Metabotropic Glutamate, Azo Compounds, Pyrrolidonecarboxylic Acid, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2016 Italy Publisher:Elsevier BVJournal:Cell Chemical Biology, volume 23, pages 887-888 (issn: 2451-9456,

Authors: NICOLETTI, Ferdinando;

doi: 10.1016/j.chembiol.2016.08.001

pmid: 27541192

handle: 11573/880291

Shedding Light on Metabotropic Glutamate Receptors

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Abstract

In this issue of Cell Chemical Biology, the elegant manuscript by Rovira et al. (2016) describes a negative allosteric modulator (NAM) of mGlu4 metabotropic glutamate receptors with in vivo activity. This compound is rapidly and reversibly inactivated by light and represents a powerful pharmacological tool for the study of mGlu4 receptors in their native environment.

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Italy

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Keywords

Biochemistry; Clinical Biochemistry; Molecular Biology; Molecular Medicine; Drug Discovery3003 Pharmaceutical Science; Pharmacology, Receptors, Metabotropic Glutamate, Azo Compounds, Pyrrolidonecarboxylic Acid

2 Research products, page 1 of 1

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu 4 Receptor Activity
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