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Bypassing AMPK Phosphorylation

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2014 English Publisher:Elsevier BVJournal:Chemistry & Biology, volume 21, pages 567-569 (issn: 1074-5521, Copyright policy )
Authors: Uwe Schlattner; Uwe Schlattner; Benoit Viollet; Benoit Viollet; Benoit Viollet; Marc Foretz; Marc Foretz; +1 Authors

doi: 10.1016/j.chembiol.2014.05.003

pmid: 24856137

Abstract

AMP-activated protein kinase (AMPK) functions as a signaling hub to balance energy supply with demand. Phosphorylation of activation loop Thr172 has been considered as an essential step in AMPK activation. In this issue of Chemistry & Biology, Scott and colleagues show that the small molecule direct AMPK activator, A-769662, bypasses this phosphorylation event and acts synergistically with AMP on naive AMPK.

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Keywords

AMPK, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Pharmacology, 570, Clinical Biochemistry, Biphenyl Compounds, 610, Thiophenes, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, AMP-Activated Protein Kinases, Biochemistry, Adenosine Monophosphate, Pyrones, Drug Discovery, Molecular Medicine, Animals, Molecular Biology, Signal Transduction

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
10
Average
Average
Top 10%
Green
hybrid