“Prohibitin”g CRAF/MAPK Activation with Rocaglamides

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2012 English Publisher:Elsevier BVJournal:Chemistry & Biology, volume 19, pages 1,077-1,078 (issn: 1074-5521,

Copyright policy )

Authors: Rajalingam, Krishnaraj; Rudel, Thomas;

doi: 10.1016/j.chembiol.2012.09.004

pmid: 22999872

“Prohibitin”g CRAF/MAPK Activation with Rocaglamides

- Summary
- Subjects
- Metrics

Abstract

Interaction with prohibitin (PHB) is required for full activation of CRAF kinase, the central member of the highly conserved RAS-CRAF-MAPK pathway. In this issue of Chemistry & Biology, Polier et al. show that the natural anti-tumor compounds rocaglamides target the CRAF-PHB interaction to disrupt the MAPK pathway leading to proliferation block in human leukemic cells.

Related Organizations

University of Würzburg
Germany
Goethe University Frankfurt
Germany

Keywords

Pharmacology, Clinical Biochemistry, Drug Discovery, Molecular Medicine, Biochemistry, Molecular Biology

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	7
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average