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Flexing and Stretching in Nonribosomal Peptide Synthetases

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2012 English Publisher:Elsevier BVJournal:Chemistry & Biology, volume 19, pages 167-169 (issn: 1074-5521, Copyright policy )
Authors: Pfennig, Sabrina; Stubbs, Milton T.;

doi: 10.1016/j.chembiol.2012.02.002

pmid: 22365598

Flexing and Stretching in Nonribosomal Peptide Synthetases

Abstract

Re-engineering of nonribosomal peptide synthetase molecular assembly lines has been hampered by a lack of detailed knowledge concerning inter-domain substrate transfer. Recent structural studies of catalytically relevant domain-domain interactions provide valuable insights into this problem (Liu et al., 2011; Sundlov et al., 2012 [in this issue of Chemistry & Biology]).

Related Organizations
Keywords

Pharmacology, Clinical Biochemistry, Drug Discovery, Molecular Medicine, Peptide Synthases, Biochemistry, Molecular Biology

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 4
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
hybrid