descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2010 English Publisher:Elsevier BVJournal:Chemistry & Biology, volume 17, pages 1,165-1,166 (issn: 1074-5521,

Authors: Gersch, Malte; Sieber, Stephan A.;

doi: 10.1016/j.chembiol.2010.11.003

pmid: 21095563

Disarming Clostridium difficile

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Abstract

In this issue, Puriet al. (2010) present inhibitors that prevent the autocatalytic activation of the clostridial toxin TcdB in vivo. Their approach is likely to provide guidance for the development of novel drugs targeting virulence factors and thereby rendering bacterial pathogens innocuous.

Related Organizations

Technical University of Munich
Germany
Max Planck Society
Germany
Center for Integrated Protein Science Munich
Germany
Ludwig-Maximilians-Universität München
Germany

Keywords

Pharmacology, Clinical Biochemistry, Drug Discovery, Molecular Medicine, Biochemistry, Molecular Biology

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