descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2007 English Publisher:Elsevier BVJournal:Chemistry & Biology, volume 14, pages 242-244 (issn: 1074-5521,

Authors: Salam Shaaban; Mark T. Bedford;

doi: 10.1016/j.chembiol.2007.03.001

pmid: 17379139

Reprogramming the Histone Code

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Abstract

Histone lysine methyltransferases, like G9a, play central roles in the regulation of gene expression. A current study by Kubicek et al. [1] reports the identification of a G9a small-molecule inhibitor, thereby opening the way to new epigenetic cancer therapies.

Related Organizations

OSI Pharmaceuticals
United States
The University of Texas System
United States
The University of Texas MD Anderson Cancer Center
United States

Keywords

Pharmacology, Clinical Biochemistry, DNA, Histone-Lysine N-Methyltransferase, DNA Methylation, Biochemistry, Gene Expression Regulation, Drug Discovery, Molecular Medicine, Enzyme Inhibitors, Molecular Biology

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