
pmid: 16931328
Riboswitches in the 5'-untranslated regions of mRNAs cotranscriptionally couple ligand binding and gene regulation. In this issue of Chemistry & Biology, Lemay et al. describe folding of a key tertiary interaction in the adenine riboswitch and its mechanistic consequences.
Pharmacology, Binding Sites, Adenine, Clinical Biochemistry, Gene Expression Regulation, Bacterial, Ligands, Biochemistry, Drug Discovery, Molecular Medicine, Nucleic Acid Conformation, RNA, 5' Untranslated Regions, Molecular Biology, Transcription Factors
Pharmacology, Binding Sites, Adenine, Clinical Biochemistry, Gene Expression Regulation, Bacterial, Ligands, Biochemistry, Drug Discovery, Molecular Medicine, Nucleic Acid Conformation, RNA, 5' Untranslated Regions, Molecular Biology, Transcription Factors
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