Adenylyl cyclases in the digestive system
Copyright policy )Adenylyl cyclases in the digestive system
Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals. In addition to the transmembrane isoforms, one AC is soluble and exhibits distinct regulation. In this review, the basic structure, regulation and physiological roles of ACs in the digestive system are discussed.
- Texas A&M University United States
- Georgia Regents University United States
- Yale University United States
- Texas A&M Health Science Center United States
- Augusta University United States
Isoenzymes, Pancreatitis, Digestive System Physiological Phenomena, Catalytic Domain, Animals, Humans, Digestive System, Adenylyl Cyclases, Signal Transduction
Isoenzymes, Pancreatitis, Digestive System Physiological Phenomena, Catalytic Domain, Animals, Humans, Digestive System, Adenylyl Cyclases, Signal Transduction
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