Beside the MEF2 axis: Unconventional functions of HDAC4
Copyright policy )Beside the MEF2 axis: Unconventional functions of HDAC4
The class IIa deacetylase HDAC4 is unequivocally known as a negative regulator of MEF2-dependent transcription. In the past years several works have allowed us to understand how different signals, mirroring specific environmental circumstances keep in check the repressive action of HDAC4 against MEF2s. At the same time, pieces of evidence have gradually accumulated about HDAC4 activities emancipated from MEF2s. The aim of this review is to discuss about these "unconventional functions" of HDAC4.
- University of Udine Italy
- AREA Science Park Italy
chromatin; HDAC; gene expression, Basic Helix-Loop-Helix Proteins, Repressor Proteins, STAT1 Transcription Factor, Myogenic Regulatory Factors, Transcription, Genetic, Humans, Forkhead Transcription Factors, Histone Deacetylases, Protein Binding
chromatin; HDAC; gene expression, Basic Helix-Loop-Helix Proteins, Repressor Proteins, STAT1 Transcription Factor, Myogenic Regulatory Factors, Transcription, Genetic, Humans, Forkhead Transcription Factors, Histone Deacetylases, Protein Binding
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