PIASy interacts with p73α and regulates cell cycle in HEK293 cells
Copyright policy )PIASy interacts with p73α and regulates cell cycle in HEK293 cells
p73, a recently described member of the p53 family of transcription factors, undergoes a number of posttranslational modifications, inducing cell cycle arrest and apoptosis. In the present study, we demonstrate that PIASy, a member of the PIAS SUMO-ligase family, interacts with p73alpha, and that PIASy-mediated sumoylation promotes proteasomal degradation of p73alpha. PIASy overexpression inhibits p73alpha-mediated transcription of p21, with a reduction of cells in G1 and cell cycle reentry. These results suggest that PIASy plays an important role in regulation of p73alpha transcriptional activity and is also a regulator of the cell cycle machinery.
- Nanjing Normal University China (People's Republic of)
- Nanjing University China (People's Republic of)
- Nanjing University China (People's Republic of)
- Nanjing Normal University China (People's Republic of)
- State Key Laboratory of Pharmaceutical Biotechnology China (People's Republic of)
Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, Cell Cycle, Immunoblotting, Gene Expression, Nuclear Proteins, Tumor Protein p73, Protein Inhibitors of Activated STAT, Cell Line, DNA-Binding Proteins, Small Ubiquitin-Related Modifier Proteins, Humans, Protein Processing, Post-Translational, Protein Binding
Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, Cell Cycle, Immunoblotting, Gene Expression, Nuclear Proteins, Tumor Protein p73, Protein Inhibitors of Activated STAT, Cell Line, DNA-Binding Proteins, Small Ubiquitin-Related Modifier Proteins, Humans, Protein Processing, Post-Translational, Protein Binding
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