Replication Timing Becomes Intertwined with 3D Genome Organization

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2019 English Publisher:Elsevier BVJournal:Cell, volume 176, pages 681-684 (issn: 0092-8674,

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Authors: Jian, Ma; Zhijun, Duan;

doi: 10.1016/j.cell.2019.01.027

pmid: 30735630

Replication Timing Becomes Intertwined with 3D Genome Organization

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Abstract

Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization. The study has important implications for unraveling control elements of high-order genome structure and function.

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Keywords

DNA Replication, Mammals, Genome, DNA Replication Timing, Animals

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