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Cell
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Cell
Article . 2018 . Peer-reviewed
License: Elsevier Non-Commercial
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https://pubmed.ncbi.nlm.nih.go...
Article . 2019
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Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2018 English Publisher:Elsevier BVJournal:Cell, volume 174, pages 1,339-1,341 (issn: 0092-8674, Copyright policy )
Authors: Haiyang, Yu; Don W, Cleveland;

doi: 10.1016/j.cell.2018.08.035

pmid: 30193106

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1

Abstract

Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together cause neuroinflammation.

Related Organizations
Keywords

Inflammation, Frontotemporal Dementia, Receptor-Interacting Protein Serine-Threonine Kinases, Amyotrophic Lateral Sclerosis, Mutation, Humans, Apoptosis, Protein Serine-Threonine Kinases

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 15
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
15
Top 10%
Average
Top 10%
hybrid