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PP1 Phosphatase Complexes: Undruggable No Longer

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2018 United Kingdom English Publisher:Elsevier BVJournal:Cell, volume 174, pages 1,049-1,051 (issn: 0092-8674, Copyright policy )Funded by:UKRI | Understanding signalling ...
Authors: Vagnarelli, P; Alessi, D;

doi: 10.1016/j.cell.2018.08.007

pmid: 30142342

PP1 Phosphatase Complexes: Undruggable No Longer

Abstract

The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.

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United Kingdom
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Keywords

Mice, /dk/atira/pure/subjectarea/asjc/1300/1300, 572, Protein Phosphatase 1, name=General Biochemistry,Genetics and Molecular Biology, 610, Animals, Phosphorylation

  • BIP!
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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 14
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Top 10%
Average
Top 10%
Green
hybrid
Related to Research communities
UArctic