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Cell
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Cell
Article . 2018 . Peer-reviewed
License: Elsevier Non-Commercial
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https://pubmed.ncbi.nlm.nih.go...
Article . 2019
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Gene Therapy for Retinal Degeneration

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2018 English Publisher:Elsevier BVJournal:Cell, volume 173, page 5 (issn: 0092-8674, Copyright policy )
Authors: Rajendra S, Apte;

doi: 10.1016/j.cell.2018.03.021

pmid: 29570997

Gene Therapy for Retinal Degeneration

Abstract

Biallelic mutations in the RPE65 gene are associated with inherited retinal degenerations/dystrophies (IRD) and disrupt the visual cycle, leading to loss of vision. A new adenoviral vector-based gene therapy surgically delivered to retinal cells provides normal human RPE65 protein that can restore the visual cycle and some vision. To view this Bench to Bedside, open or download the PDF.

Related Organizations
Keywords

cis-trans-Isomerases, Genetic Vectors, Leber Congenital Amaurosis, Retinal Degeneration, Humans, Genetic Therapy, Adenoviridae, Retinoid Isomerohydrolase

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 62
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
Powered by OpenAIRE graph
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
62
Top 10%
Top 10%
Top 1%
hybrid