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Metazoan MicroRNAs

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2018 United States English Publisher:Elsevier BVJournal:Cell, volume 173, pages 20-51 (issn: 0092-8674, Copyright policy )
Authors: Bartel, David;

doi: 10.1016/j.cell.2018.03.006

pmid: 29570994

pmc: PMC6091663

handle: 1721.1/126005

Metazoan MicroRNAs

Abstract

MicroRNAs (miRNAs) are ∼22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution. It then reviews how metazoan miRNAs are regulated, how they recognize and cause repression of their targets, and the biological functions of this repression, with a compilation of knockout phenotypes that shows that important biological functions have been identified for most of the broadly conserved miRNAs of mammals.

Country
United States
Related Organizations
Keywords

Evolution, Molecular, MicroRNAs, Gene Expression Regulation, RNA Isoforms, Animals, Humans, Nucleic Acid Conformation, Gene Silencing, Genomics, Base Pairing

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    popularity
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3K
Top 0.01%
Top 0.1%
Top 0.01%
Green
hybrid