SnapShot: Functions of Endoplasmic Reticulum Membrane Contact Sites

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2017 English Publisher:Elsevier BVJournal:Cell, volume 171, pages 1,224-12,240 (issn: 0092-8674,

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Authors: Raquel, Salvador-Gallego; Melissa J, Hoyer; Gia K, Voeltz;

doi: 10.1016/j.cell.2017.11.005

pmid: 29149609

SnapShot: Functions of Endoplasmic Reticulum Membrane Contact Sites

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Abstract

The endoplasmic reticulum (ER) consists of the nuclear envelope and a reticulated interconnected network of tubules and sheets. ER sheets are studded with ribosomes and provide the entryway for proteins into the secretory pathway. ER tubules move dynamically on microtubules and form membrane contact sites with other organelles, where membranes are tethered, but not fused. This Snapshot reviews key biological processes that take place at ER contact sites with the Golgi, endosomes, and mitochondria.

Related Organizations

University of Colorado Boulder
United States
University of Colorado System
United States

Keywords

Animals, Humans, Proteins, Biological Transport, Calcium, Endoplasmic Reticulum, Lipid Metabolism

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