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Cell
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Cell
Article . 2017 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
https://pubmed.ncbi.nlm.nih.go...
Article . 2017
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/j.c...
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Huntingtin Fibrils Poke Membranes

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2017 English Publisher:Elsevier BVJournal:Cell, volume 171, pages 32-33 (issn: 0092-8674, Copyright policy )
Authors: Pedro, Guedes-Dias; Erika L F, Holzbaur;

doi: 10.1016/j.cell.2017.09.009

pmid: 28938121

Huntingtin Fibrils Poke Membranes

Abstract

A hallmark of Huntington's disease is the presence of intracellular aggregates of mutant huntingtin, the pathological significance of which has long been debated. Using cryo-electron tomography, Bauerlein et al. reveal the fibrillary structure of huntingtin aggregates in situ and show that huntingtin fibrils interact with the endoplasmic reticulum, distorting its morphology and dynamics.

Related Organizations
Keywords

Huntingtin Protein, Huntington Disease, Animals, Humans, Nuclear Proteins, Nerve Tissue Proteins, Endoplasmic Reticulum

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 6
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
6
Top 10%
Average
Average
hybrid